Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.

@article{Lahair2006MolecularPL,
  title={Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.},
  author={Michelle M Lahair and Christopher J. Howe and Oswaldo G Rodr{\'i}guez-Mora and James A McCubrey and Richard A. Franklin},
  journal={Antioxidants & redox signaling},
  year={2006},
  volume={8 9-10},
  pages={
          1749-56
        }
}
Oxidative stress can activate a variety of intracellular signaling pathways. The authors previously reported the CaM-K inhibitor KN-93 inhibited hydrogen peroxide-induced phosphorylation of Akt on threonine 308 (T308). In this report they demonstrate that phosphorylation of T308 in response to hydrogen peroxide treatment is not inhibited by LY294002, suggesting that phosphorylation of this residue in response to oxidative stress is largely PI3K independent. In contrast, hydrogen peroxide… CONTINUE READING

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