Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

@article{Blum2001MolecularPI,
  title={Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease},
  author={D. Blum and S. Torch and N. Lambeng and M. Nissou and A. Benabid and R. Sadoul and J. Verna},
  journal={Progress in Neurobiology},
  year={2001},
  volume={65},
  pages={135-172}
}
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential loss of the dopaminergic neurons of the substantia nigra pars compacta. Although the etiology of PD is unknown, major biochemical processes such as oxidative stress and mitochondrial inhibition are largely described. However, despite these findings, the actual therapeutics are essentially symptomatical and are not able to block the degenerative process. Recent histological studies performed on brains from… Expand
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease.
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References

SHOWING 1-10 OF 485 REFERENCES
Distinct Mechanisms Underlie Neurotoxin-Mediated Cell Death in Cultured Dopaminergic Neurons
  • Julie Lotharius, Laura L. Dugan, Karen L. O’Malley
  • Biology, Medicine
  • The Journal of Neuroscience
  • 1999
Cell death mechanisms in Parkinson's disease
  • K. Jellinger
  • Biology, Medicine
  • Journal of Neural Transmission
  • 2000
The toxicity of 6-hydroxydopamine on PC12 and P19 cells.
...
1
2
3
4
5
...