Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.

@article{Pot2010MolecularPI,
  title={Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.},
  author={Caroline Pot and Lionel Apetoh and Amit Awasthi and Vijay K Kuchroo},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2010},
  volume={30 6},
  pages={
          381-8
        }
}
Type 1 regulatory (Tr1) cells have emerged as key players in the prevention of autoimmunity. They produce high levels of the immunosuppressive cytokine interleukin (IL)-10 and confer protection against a wide panel of autoimmune diseases. However, the molecular pathways leading to their generation have long remained elusive. We have recently identified IL-27, a member of the IL-12 cytokine family, as a novel cytokine that induces Tr1 cells. Further analysis of IL-27-driven Tr1 cells have… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

Similar Papers

Loading similar papers…