Molecular pathways in sporadic PD.

  title={Molecular pathways in sporadic PD.},
  author={Enza Maria Valente and Giuseppe Arena and L. Torosantucci and Vania Gelmetti},
  journal={Parkinsonism & related disorders},
  volume={18 Suppl 1},
Over the last decade, several autosomal dominant and recessive genes causative of Parkinson's disease (PD) have been identified. The functional studies on their protein products and the pathogenetic effect related to their mutations have greatly contributed to understand the many cellular pathways leading to neurodegeneration, that include oxidative stress damage, mitochondrial dysfunction, misfolded protein stress and impairment of cellular clearance systems, namely the ubiquitin-proteasome… CONTINUE READING

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