Molecular pathways in head and neck cancer: EGFR, PI3K, and more.

@article{Psyrri2013MolecularPI,
  title={Molecular pathways in head and neck cancer: EGFR, PI3K, and more.},
  author={Amanda K. Psyrri and Tanguy Y. Seiwert and Antonio J. Jimeno},
  journal={American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting},
  year={2013},
  pages={
          246-55
        }
}
The treatment of head and neck squamous cell carcinoma (HNSCC) is set to undergo rapid changes, as novel treatment targets informed by genomic profiling and novel molecularly targeted therapies continue to make strides. In this review we provide an overview of the latest developments regarding (1) EGFR targeting for HNSCC, (2) PI3K as a novel treatment target, and (3) newly described key genetic events in HNSCC such as NOTCH1 mutations and emerging candidate targets including ALK1 and hedgehog… CONTINUE READING

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