Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity.

@article{Ridnour2013MolecularPT,
  title={Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity.},
  author={Lisa A. Ridnour and Robert Y. S. Cheng and Christopher H. Switzer and Julie L. Heinecke and Stefan Ambs and Sharon A Glynn and Howard A Young and Giorgio Trinchieri and David A Wink},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 6},
  pages={1340-6}
}
Numerous reports have described Toll-like receptor (TLR) expression in the tumor microenvironment as it relates to cancer progression, as well as their involvement in inflammation. While TLRs mediate immune surveillance, clinical studies have associated TLR expression in the tumor with poor patient survival, indicating that TLR expression may affect cancer treatment and survival. This review will examine mechanisms in which TLR activation upregulates protumorigenic pathways, including the… CONTINUE READING