Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma.

@article{Carbone2012MolecularPT,
  title={Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma.},
  author={Michele Carbone and Haining Yang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 3},
  pages={598-604}
}
Malignant mesothelioma is an aggressive malignancy related to asbestos and erionite exposure. AP-1 transcriptional activity and the NF-κB signaling pathway have been linked to mesothelial cell transformation and tumor progression. HGF and c-Met are highly expressed in mesotheliomas. Phosphoinositide 3-kinase, AKT, and the downstream mTOR are involved in cell growth and survival, and they are often found to be activated in mesothelioma. p16(INK4a) and p14(ARF) are frequently inactivated in human… CONTINUE READING