Molecular pathways: protein methyltransferases in cancer.

  title={Molecular pathways: protein methyltransferases in cancer.},
  author={Robert A Copeland},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={19 23},
The protein methyltransferases (PMT) constitute a large and important class of enzymes that catalyze site-specific methylation of lysine or arginine residues on histones and other proteins. Site-specific histone methylation is a critical component of chromatin regulation of gene transcription-a pathway that is often genetically altered in human cancers. Oncogenic alterations (e.g., mutations, chromosomal translocations, and others) of PMTs, or of associated proteins, have been found to confer… CONTINUE READING


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