Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment.

@article{Connolly2013MolecularPC,
  title={Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment.},
  author={Roisin M Connolly and Nguyen Thi Kim Nguyen and Saraswati V. Sukumar},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 7},
  pages={1651-9}
}
Retinoids and their naturally metabolized and synthetic products (e.g., all-trans retinoic acid, 13-cis retinoic acid, bexarotene) induce differentiation in various cell types. Retinoids exert their actions mainly through binding to the nuclear retinoic acid receptors (α, β, γ), which are transcriptional and homeostatic regulators with functions that are often compromised early in neoplastic transformation. The retinoids have been investigated extensively for their use in cancer prevention and… CONTINUE READING
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