Molecular pathways: YAP and TAZ take center stage in organ growth and tumorigenesis.

@article{Piccolo2013MolecularPY,
  title={Molecular pathways: YAP and TAZ take center stage in organ growth and tumorigenesis.},
  author={Stefano Piccolo and Michelangelo Cordenonsi and Sirio Dupont},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 18},
  pages={4925-30}
}
The evolution of a solid tumor is fueled by genetic aberrations. Yet, the tumor environment often dominates over the effects of genetics: normal tissues have powerful tumor-suppressive properties that constantly tame or eliminate cells carrying transforming mutations. Critical elements of such a suppressive microenvironment are structural characteristics of normal cells and tissues, such as cell polarity, attachment to the extracellular matrix (ECM), and epithelial organization. Once these… CONTINUE READING

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Coordination of growth and cell division in theDrosophilawing

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Highly Influential
3 Excerpts

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