Molecular pathways: ROS1 fusion proteins in cancer.

  title={Molecular pathways: ROS1 fusion proteins in cancer.},
  author={Kurtis D. Davies and Robert C Doebele},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={19 15},
Genetic alterations that lead to constitutive activation of kinases are frequently observed in cancer. In many cases, the growth and survival of tumor cells rely upon an activated kinase such that inhibition of its activity is an effective anticancer therapy. ROS1 is a receptor tyrosine kinase that has recently been shown to undergo genetic rearrangements in a variety of human cancers, including glioblastoma, non-small cell lung cancer (NSCLC), cholangiocarcinoma, ovarian cancer, gastric… CONTINUE READING
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