Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer.

  title={Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer.},
  author={Roberta Ferraldeschi and Nima Sharifi and Richard J Auchus and Gerhardt Attard},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={19 13},
A significant proportion of castration-resistant prostate cancers (CRPC) remains driven by ligand activation of the androgen receptor. Although the testes are the primary source of testosterone, testosterone can also be produced from peripheral conversion of adrenal sex hormone precursors DHEA and androstenedione in the prostate and other tissues. CYP17A1 catalyzes two essential reactions in the production of DHEA and androstenedione: the hydroxylation (hydroxylase activity) and the subsequent… CONTINUE READING