Molecular pathway for the localized formation of the sinoatrial node.

@article{Mommersteeg2007MolecularPF,
  title={Molecular pathway for the localized formation of the sinoatrial node.},
  author={Mathilda T. M. Mommersteeg and Willem M. H. Hoogaars and Owen W.J. Prall and Corrie de Gier-de Vries and Cornelia Wiese and Danielle E.W. Clout and Virginia E Papaioannou and Nigel Brown and Richard P. Harvey and Antoon F. M. Moorman and Vincent M Christoffels},
  journal={Circulation research},
  year={2007},
  volume={100 3},
  pages={354-62}
}
The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been defined. Here we show that subsequent to the formation of the Nkx2-5-positive heart tube, cells bordering the inflow tract of the heart tube give rise to the Nkx2-5-negative myocardial… CONTINUE READING

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