Molecular pathophysiology of cerebral hemorrhage: secondary brain injury.

  title={Molecular pathophysiology of cerebral hemorrhage: secondary brain injury.},
  author={Jaroslaw Aronowski and Xiurong Zhao},
  volume={42 6},
Intracerebral hemorrhage (ICH) is an often fatal type of stroke that kills approximately 30,000 people annually in the United States. If the patient survives the ictus, then the resulting hematoma within brain parenchyma triggers a series of adverse events causing secondary insults and severe neurological deficits. This article discusses selected aspects of secondary brain injury after ICH and outlines key mechanisms associated with hematoma toxicity, oxidative stress, and inflammation. Finally… CONTINUE READING
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