Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels

Abstract

Voltage-gated ion channels (VGICs) are membrane proteins that switch from a closed to open state in response to changes in membrane potential, thus enabling ion fluxes across the cell membranes. The mechanism that regulate the structural rearrangements occurring in VGICs in response to changes in membrane potential still remains one of the most challenging… (More)
DOI: 10.3389/fncel.2015.00259

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