Molecular pathology of well-differentiated thyroid carcinomas

  title={Molecular pathology of well-differentiated thyroid carcinomas},
  author={Manuel Sobrinho-Sim{\~o}es and Ana Preto and Ana Sofia Rocha and Patricia Miranda Castro and Valdemar M{\'a}ximo and Elsa Fonseca and Paula Soares},
  journal={Virchows Archiv},
The newly discovered molecular features of well-differentiated thyroid carcinomas derived from follicular cells are reviewed, within the frame of the 2004 WHO classification of thyroid tumours, under the following headings: “Follicular carcinoma”, “Papillary carcinoma”, “Follicular variant of papillary carcinoma” and “Hürthle cell tumours”. A particular emphasis is put on the meaning of PAX8–PPARγ rearrangements, RAS and BRAF mutations, and deletions and mutations of mitochondrial genes and of… CONTINUE READING