Molecular pathology of lung cancer: key to personalized medicine

  title={Molecular pathology of lung cancer: key to personalized medicine},
  author={Liang Cheng and Riley E. Alexander and Gregory T. Maclennan and O William Cummings and Rodolfo Montironi and Antonio Lopez-Beltran and Harvey M. Cramer and Darrell D. Davidson and Shaobo Zhang},
  journal={Modern Pathology},
The majority of lung adenocarcinoma patients with epidermal growth factor receptor- (EGFR) mutated or EML4–ALK rearrangement-positive tumors are sensitive to tyrosine kinase inhibitors. Both primary and acquired resistance in a significant number of those patients to these therapies remains a major clinical problem. The specific molecular mechanisms associated with tyrosine kinase inhibitor resistance are not fully understood. Clinicopathological observations suggest that molecular alterations… CONTINUE READING
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