Molecular pathology of early stage chemically induced hepatocarcinogenesis.

  title={Molecular pathology of early stage chemically induced hepatocarcinogenesis.},
  author={Katsuhiro Ogawa},
  journal={Pathology international},
  volume={59 9},
In the early stage of chemically induced hepatocarcinogenesis, rare hepatocytes are transformed into preneoplastic hepatocytes, which progressively evolve into cells with increasing neoplastic phenotypes. Preneoplastic hepatocytes have gene expression different from normal hepatocytes, presumably from the outset. Some of these gene products are related to the growth and survival of the preneoplastic hepatocytes themselves, while others seem to involve the interaction of preneoplastic… CONTINUE READING


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