Molecular pathology of MELAS and L-arginine effects.


BACKGROUND The pathogenic mechanism of stroke-like episodes seen in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) has not been clarified yet. About 80% of MELAS patients have an A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene, which is the base change at position 14 in the consensus structure of tRNA(Leu… (More)
DOI: 10.1016/j.bbagen.2011.09.005


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@article{Koga2012MolecularPO, title={Molecular pathology of MELAS and L-arginine effects.}, author={Yasutoshi Koga and Nataliya Povalko and Junko Nishioka and Koujyu Katayama and Shuichi Yatsuga and Toyojiro Matsuishi}, journal={Biochimica et biophysica acta}, year={2012}, volume={1820 5}, pages={608-14} }