Molecular pathology and pathobiology of osteoarthritic cartilage

Abstract

The biochemical properties of articular cartilage rely on the biochemical composition and integrity of its extracellular matrix. This matrix consists mainly of a collagen network and the proteoglycan-rich ground substance. In osteoarthritis, ongoing cartilage matrix destruction takes place, leading to a progressive loss in joint function. Beside the… (More)
DOI: 10.1007/s00018-002-8400-3

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