Molecular pathology and immunology of factor VIII (hemophilia A and factor VIII inhibitors).

@article{Hoyer1987MolecularPA,
  title={Molecular pathology and immunology of factor VIII (hemophilia A and factor VIII inhibitors).},
  author={Leon W. Hoyer},
  journal={Human pathology},
  year={1987},
  volume={18 2},
  pages={153-61}
}
Factor VIII is a large procoagulant glycoprotein that circulates in plasma in a noncovalent complex with von Willebrand factor. It is essential for the efficient cleavage of coagulation factor X by factor IXa, and its absence causes a severe bleeding disorder. Plasma factor VIII is reduced from the normal range of approximately 100 to 200 ng/ml in patients… CONTINUE READING