Molecular pathology, classification, and diagnosis of sporadic human prion disease variants.

@article{Parchi2012MolecularPC,
  title={Molecular pathology, classification, and diagnosis of sporadic human prion disease variants.},
  author={Piero Parchi and Daniela Saverioni},
  journal={Folia neuropathologica},
  year={2012},
  volume={50 1},
  pages={20-45}
}
Human prion diseases are a unique group of transmissible neurodegenerative diseases that occur as sporadic, familial or acquired disorders and show a wide range of phenotypic variation. The latter has been attributed to the existence of distinct strains of the agent or prion, and the genetic background of the host, namely the primary sequence of the gene encoding the prion protein, which is the site of mutations and polymorphisms. The characterization of distinct isoforms of the abnormal prion… CONTINUE READING
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