Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease

@article{Ogino2013MolecularPE,
  title={Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease},
  author={S. Ogino and P. Lochhead and A. Chan and R. Nishihara and E. Cho and B. Wolpin and J. Meyerhardt and A. Meissner and E. Schernhammer and C. Fuchs and E. Giovannucci},
  journal={Modern Pathology},
  year={2013},
  volume={26},
  pages={465-484}
}
Epigenetics acts as an interface between environmental/exogenous factors, cellular responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of complex multifactorial diseases (including neoplasms and malignancies such as leukemias, lymphomas, sarcomas, and breast, lung, prostate, liver, and colorectal cancers). Epigenetic signatures (DNA methylation, mRNA and microRNA expression, etc) may serve as biomarkers for risk stratification, early detection, and disease… Expand
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