Molecular pathogenesis of multiple myeloma.

  title={Molecular pathogenesis of multiple myeloma.},
  author={Giovanni Tonon},
  journal={Hematology/oncology clinics of North America},
  volume={21 6},
  pages={985-1006, vii}
  • Giovanni Tonon
  • Published 2007 in Hematology/oncology clinics of North America
Several genetic mechanisms underlying the pathogenesis of multiple myeloma have been elucidated in the past decade. In particular, the presence of two distinct karyotypic patterns, that identify two patient groups and drive different pathogenetic and prognostic paths in the development of myeloma, have been identified, and the role of reciprocal chromosomal translocations and cyclin dysregulation have been identified. Despite this progress, several questions of critical importance remain to be… CONTINUE READING