Molecular pathogenesis of human hepatocellular carcinoma

Abstract

Hepatocarcinogenesis is a slow process during which genomic changes progressively alter the hepatocellular phenotype to produce cellular intermediates that evolve into hepatocellular carcinoma. During the long preneoplastic stage, in which the liver is often the site of chronic hepatitis, cirrhosis, or both, hepatocyte cycling is accelerated by upregulation… (More)
DOI: 10.1038/ng0802-339

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@article{Thorgeirsson2002MolecularPO, title={Molecular pathogenesis of human hepatocellular carcinoma}, author={Snorri Thorgeirsson and Joe W. Grisham}, journal={Nature Genetics}, year={2002}, volume={31}, pages={339-346} }