Molecular pathogenesis of cholestasis.

@article{Trauner1998MolecularPO,
  title={Molecular pathogenesis of cholestasis.},
  author={Michael Trauner and Peter J. Meier and James L Boyer},
  journal={The New England journal of medicine},
  year={1998},
  volume={339 17},
  pages={
          1217-27
        }
}
The formation of bile is a vital function, and its impairment by drugs or infectious, autoimmune, metabolic, or genetic disorders results in the syndrome commonly known as cholestasis.1 The secreti... 
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    This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.
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    The role of p53 in the regulation of bile acid disposition and cholestasis is investigated and it is found that it contributes to metabolic diseases.
    Drug- and chemical-induced cholestasis.
    Intrahepatic cholestasis in common chronic liver diseases
    TLDR
    The aim now was to summarise the current state of knowledge on intrahepatic cholestasis related to chronic liver diseases.
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