Molecular pathogenesis of T-cell leukaemia and lymphoma

  title={Molecular pathogenesis of T-cell leukaemia and lymphoma},
  author={Iannis Aifantis and Elizabeth A. Raetz and Silvia Buonamici},
  journal={Nature Reviews Immunology},
T-cell acute lymphoblastic leukaemia (T-ALL) is induced by the transformation of T-cell progenitors and mainly occurs in children and adolescents. Although treatment outcome in patients with T-ALL has improved in recent years, patients with relapsed disease continue to have a poor prognosis. It is therefore important to understand the molecular pathways that control both the induction of transformation and the treatment of relapsed disease. In this Review, we focus on the molecular mechanisms… CONTINUE READING
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