Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.

@article{Schroeder2008MolecularPO,
  title={Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.},
  author={Gunnar N. Schroeder and Hubert Hilbi},
  journal={Clinical microbiology reviews},
  year={2008},
  volume={21 1},
  pages={134-56}
}
Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research performed over the last 25 years revealed that a type III secretion system (T3SS) encoded on a large plasmid is a key virulence factor of Shigella flexneri. The T3SS determines the interactions of S. flexneri with intestinal cells by consecutively translocating two sets of effector proteins into the target cells. Thus, S. flexneri… CONTINUE READING
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