Molecular pathogenesis of Parkinson disease: insights from genetic studies.

@article{Gasser2009MolecularPO,
  title={Molecular pathogenesis of Parkinson disease: insights from genetic studies.},
  author={Thomas Gasser},
  journal={Expert reviews in molecular medicine},
  year={2009},
  volume={11},
  pages={e22}
}
Over the past few years, genetic findings have changed our views on the molecular pathogenesis of Parkinson disease (PD), as mutations in a growing number of genes have been found to cause monogenic forms of the disorder. These mutations cause neuronal dysfunction and neurodegeneration either by a toxic gain of function, as in the case of the dominant forms of monogenic PD caused by mutations in the genes for alpha-synuclein or LRRK2, or by a loss of an intrinsic protective function, as is… CONTINUE READING
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