Molecular parameters of genome instability: roles of fragile genes at common fragile sites.

  title={Molecular parameters of genome instability: roles of fragile genes at common fragile sites.},
  author={Flavia Pichiorri and Hideshi Ishii and Hiroshi Okumura and Francesco Trapasso and Ya Wang and Kay F Huebner},
  journal={Journal of cellular biochemistry},
  volume={104 5},
Common chromosome fragile sites occur at specific sequences within mammalian genomes that exhibit apparent single-stranded regions in mitotic chromosomes on exposure of cells to replication stress. Recent progress in the characterization of sequences, and more precise mapping of common fragile sites in mammalian and yeast genomes, has led to the exact placement of large common fragile regions straddling the borders of chromosomal G and R bands, with early and late replicating genomic regions… CONTINUE READING


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