Molecular origins of rapid and continuous morphological evolution.

@article{Fondon2004MolecularOO,
  title={Molecular origins of rapid and continuous morphological evolution.},
  author={John W. Fondon and Harold R. Garner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 52},
  pages={18058-63}
}
Mutations in cis-regulatory sequences have been implicated as being the predominant source of variation in morphological evolution. We offer a hypothesis that gene-associated tandem repeat expansions and contractions are a major source of phenotypic variation in evolution. Here, we describe a comparative genomic study of repetitive elements in developmental genes of 92 breeds of dogs. We find evidence for selection for divergence at coding repeat loci in the form of both elevated purity and… CONTINUE READING
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