Molecular origin of the cation selectivity in OmpF porin: single channel conductances vs. free energy calculation.

@article{Danelon2003MolecularOO,
  title={Molecular origin of the cation selectivity in OmpF porin: single channel conductances vs. free energy calculation.},
  author={Christophe Danelon and Atsushi Suenaga and Mathias Winterhalter and Ichiro Yamato},
  journal={Biophysical chemistry},
  year={2003},
  volume={104 3},
  pages={591-603}
}
Ion current through single outer membrane protein F (OmpF) trimers was recorded and compared to molecular dynamics simulation. Unidirectional insertion was revealed from the asymmetry in channel conductance. Single trimer conductance showed particularly high values at low symmetrical salt solution. The conductance values of various alkali metal ion solutions were proportional to the monovalent cation mobility values in the bulk phase, LiCl<NaCl<KCl<RbCl approximately CsCl, but the conductance… CONTINUE READING

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