Molecular organization of transverse tubule/sarcoplasmic reticulum junctions during development of excitation-contraction coupling in skeletal muscle.

@article{Flucher1994MolecularOO,
  title={Molecular organization of transverse tubule/sarcoplasmic reticulum junctions during development of excitation-contraction coupling in skeletal muscle.},
  author={Bernhard E Flucher and S. Brian Andrews and Mathew P. Daniels},
  journal={Molecular biology of the cell},
  year={1994},
  volume={5 10},
  pages={1105-18}
}
The relationship between the molecular composition and organization of the triad junction and the development of excitation-contraction (E-C) coupling was investigated in cultured skeletal muscle. Action potential-induced calcium transients develop concomitantly with the first expression of the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR), which are colocalized in clusters from the time of their earliest appearance. These DHPR/RyR clusters correspond to junctional domains of… CONTINUE READING