Molecular organization of target of rapamycin complex 2.

@article{Wullschleger2005MolecularOO,
  title={Molecular organization of target of rapamycin complex 2.},
  author={Stephan Wullschleger and Robbie Loewith and Wolfgang Oppliger and Michael N. Hall},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 35},
  pages={
          30697-704
        }
}
The target of rapamycin (TOR), a highly conserved serine/threonine kinase, plays a central role in the control of eukaryotic cell growth. TOR exists in two functionally and structurally distinct complexes, TOR complex 1 (TORC1) and TOR complex 2 (TORC2). TORC1 controls cell growth via a rapamycin-sensitive signaling branch regulating translation, transcription, nutrient uptake, ribosome biogenesis, and autophagy. TORC2 controls the organization of the actin cytoskeleton through a rapamycin… CONTINUE READING

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