Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus.

@article{Ferlenghi2001MolecularOO,
  title={Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus.},
  author={I Ferlenghi and Margaret Clarke and Thomas Ruttan and Steven L. Allison and Juliane Schalich and Franz X Heinz and Stephen C Harrison and F{\'e}lix A Rey and Stephen D. Fuller},
  journal={Molecular cell},
  year={2001},
  volume={7 3},
  pages={593-602}
}
The tick-borne encephalitis (TBE) flavivirus contains two transmembrane proteins, E and M. Coexpression of E and the M precursor (prM) leads to secretion of recombinant subviral particles (RSPs). In the most common form of these RSPs, analyzed at a 19 A resolution by cryo-electron microscopy (cryo-EM), 60 copies of E pack as dimers in a T = 1 icosahedral… CONTINUE READING