Molecular orbital studies on the conformations of 8-amino- and 8-dimethylaminoadenosine 5'-monophosphate.

@article{Pohorille1978MolecularOS,
  title={Molecular orbital studies on the conformations of 8-amino- and 8-dimethylaminoadenosine 5'-monophosphate.},
  author={Andrew Pohorille and David P{\'e}rahia and Bernard Pullman},
  journal={Biochimica et biophysica acta},
  year={1978},
  volume={517 2},
  pages={
          511-6
        }
}
13 Citations

Theoretical studies of nucleic acid conformation: potential energies, chain statistics, and model building

The collected results provide considerable insight into the influence of primary covalent bond structure upon the three-dimensional geometry of these macromolecules and additionally clarify the relationship between the various spatial arrangements and the configuration-dependent properties of the polynucleotide as a whole.

Synthesis of oxygen-linked 8-phenoxyl-deoxyguanosine nucleoside analogues.

A relatively facile synthesis of O-linked 8-dG phenol adducts with a wide variety of electron-donating, electron-withdrawing, and sterically demanding phenols is reported.

Enzymatic Incorporation of Modified Purine Nucleotides in DNA

The experiments demonstrated that small differences in the structure might lead to significant differences in recognition efficiency and selectivity, base pairing by Hoogsteen recognition at the polymerase level is possible, and 8‐aza‐9‐deazaguanine represents a self‐complementary base pair.

Isoleucyl-tRNA synthetase from Baker's yeast. Action of ATP analogs in pyrophosphate exchange and aminoacylation, two pathways of the aminoacylation depending on concentration of pyrophosphate.

The order of substrate addition to isoleucyl-tRNA synthetase from baker's yeast has been investigated by steady-state kinetics with inhibition by four different inhibiting ATP analogs acting

ATP analog specificity of cAMP-dependent protein kinase, cGMP-dependent protein kinase, and phosphorylase kinase.

The data suggest general similarities between the ATP sites of the two homologous cyclic-nucleotide-dependent protein kinases, but specific differences especially in the adenine binding pocket are indicated, suggesting potentially useful ATP analog inhibitors of each kinase.

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