Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: expression of canonical variable regions and their variants in vaccinated infants.

@article{Lucas2003MolecularOO,
  title={Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: expression of canonical variable regions and their variants in vaccinated infants.},
  author={Alexander H. Lucas and Gary R McLean and Donald C. Reason and Adam P O'Connor and Mistique C. Felton and Karen D Moulton},
  journal={Clinical immunology},
  year={2003},
  volume={108 2},
  pages={119-27}
}
A structurally conserved antibody combining site, encoded by the IGH V3-23 and kappa A2 variable (V) region gene segments, predominates the adult immune response to the Haemophilus influenzae type b (Hib) capsular polysaccharide (PS). This site has been elevated to canonical status based upon its relative molecular uniformity and prevalence in adults. To… CONTINUE READING