Molecular nexopathies: a new paradigm of neurodegenerative disease

  title={Molecular nexopathies: a new paradigm of neurodegenerative disease},
  author={Jason D Warren and Jonathan D. Rohrer and Jonathan M. Schott and Nick C. Fox and John Hardy and Martin Rossor},
  booktitle={Trends in Neurosciences},
Neural networks provide candidate substrates for the spread of proteinopathies causing neurodegeneration, and emerging data suggest that macroscopic signatures of network disintegration differentiate diseases. However, how do protein abnormalities produce network signatures? The answer may lie with 'molecular nexopathies': specific, coherent conjunctions of pathogenic protein and intrinsic network characteristics that define network signatures of neurodegenerative pathologies. Key features of… CONTINUE READING
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