• DOI:10.3109/00952990.2014.933840
Corpus ID: 19157711

Molecular neurobiology of addiction: what’s all the (Δ)FosB about?

@article{Ruffle2014MolecularNO,
  title={Molecular neurobiology of addiction: what’s all the ($\Delta$)FosB about?},
  author={J. Ruffle},
  journal={The American Journal of Drug and Alcohol Abuse},
  year={2014},
  volume={40},
  pages={428 - 437}
}

• J. Ruffle
• Published 2014
• Biology, Medicine
• The American Journal of Drug and Alcohol Abuse

Abstract The transcription factor ΔFosB is upregulated in numerous brain regions following repeated drug exposure. This induction is likely to, at least in part, be responsible for the mechanisms underlying addiction, a disorder in which the regulation of gene expression is thought to be essential. In this review, we describe and discuss the proposed role of ΔFosB as well as the implications of recent findings. The expression of ΔFosB displays variability dependent on the administered substance… Expand