Molecular neurobiology of addiction: what’s all the (Δ)FosB about?

@article{Ruffle2014MolecularNO,
  title={Molecular neurobiology of addiction: what’s all the ($\Delta$)FosB about?},
  author={James K Ruffle},
  journal={The American Journal of Drug and Alcohol Abuse},
  year={2014},
  volume={40},
  pages={428 - 437}
}
  • J. Ruffle
  • Published 24 October 2014
  • Biology
  • The American Journal of Drug and Alcohol Abuse
Abstract The transcription factor ΔFosB is upregulated in numerous brain regions following repeated drug exposure. This induction is likely to, at least in part, be responsible for the mechanisms underlying addiction, a disorder in which the regulation of gene expression is thought to be essential. In this review, we describe and discuss the proposed role of ΔFosB as well as the implications of recent findings. The expression of ΔFosB displays variability dependent on the administered substance… 
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The first evidence of FosB gene expression in human HPC and PFC in these psychiatric disorders is provided, and data suggest that reduced ΔFosB in HPC could potentially underlie cognitive deficits accompanying chronic cocaine abuse or depression.
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Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens
Region-specific changes in markers of neuroplasticity revealed in HIV-1 transgenic rats by low-dose methamphetamine
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Results reveal a region-specific activation of ERK, and increases in ΔFosB and D1R expression induced by HIV-1 proteins and meth, which may contribute to the neuronal and behavioral pathology associated with meth/HIV comorbidity.
Pharmacological modulation of protein kinases as a new approach to treat addiction to cocaine and opiates.
Dopamine and ALK4 signaling synergize to induce PCBP1-mediated alternative splicing of FosB and sustained behavioral sensitization to cocaine
TLDR
It is reported that dopamine D1 receptor signaling synergizes with the activin/ALK4/Smad3 pathway to potentiate the generation of ΔFosB mRNA in medium spiny neurons of the nucleus-accumbens (NAc) through activation of the RNA binding protein PCBP1, a regulator of mRNA splicing.
Nicotine-induced CREB and DeltaFosB activity is modified by caffeine in the brain reward system of the rat
Effect of morphine exposure on novel object memory of the offspring: The role of histone H3 and ΔFosB
Effects of morphine withdrawal on the membrane properties of medium spiny neurons in the nucleus accumbens shell
Gene Expression Survey of Serotonin Receptors (5HTR2A and 5HTR3A) and Monoamine Oxidases Enzyme After Treatment With Methadone in Addicted Individuals
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The results suggest that Methadone Maintenance Treatment (MMT) may be moderated by 5HT2Ra and 5 HT3Ra serotonin receptors and returned to their previous efficacy, but MAOA was significantly reduced.
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References

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TLDR
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TLDR
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