Molecular motors: the driving force behind mammalian left-right development.

  title={Molecular motors: the driving force behind mammalian left-right development.},
  author={Dorothy M Supp and S. Steven Potter and Martina Brueckner},
  journal={Trends in cell biology},
  volume={10 2},
The molecular motors dynein and kinesin are large protein complexes that convert the energy generated by ATP hydrolysis into directional movement along the microtubule cytoskeleton. They are required for a myriad of cellular processes, including mitotic spindle movement, axonal and vesicular transport, and ciliary beating. Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early… CONTINUE READING


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