Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila

@inproceedings{Reis2012MolecularMF,
  title={Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila},
  author={Gerald F. Reis and Ge Yang and Lukasz Szpankowski and Carole Weaver and Sameer B. Shah and John T. Robinson and Thomas S Hays and Gaudenz Danuser and Lawrence S. B. Goldstein},
  booktitle={Molecular biology of the cell},
  year={2012}
}
Bidirectional axonal transport driven by kinesin and dynein along microtubules is critical to neuronal viability and function. To evaluate axonal transport mechanisms, we developed a high-resolution imaging system to track the movement of amyloid precursor protein (APP) vesicles in Drosophila segmental nerve axons. Computational analyses of a large number of moving vesicles in defined genetic backgrounds with partial reduction or overexpression of motor proteins enabled us to test with high… CONTINUE READING

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viability by amyloid precursor protein mutations in Drosophila

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