Molecular monitoring of chronic myeloid leukemia: principles and interlaboratory standardization

@article{Cross2015MolecularMO,
  title={Molecular monitoring of chronic myeloid leukemia: principles and interlaboratory standardization},
  author={Nicholas C P Cross and Andreas Hochhaus and Martin Christian M{\"u}ller},
  journal={Annals of Hematology},
  year={2015},
  volume={94},
  pages={219-225}
}
Serial quantification of BCR-ABL1 messenger RNA (mRNA) is an important therapeutic indicator for patients with chronic myeloid leukemia, but historically, there has been substantial variation in results reported by different laboratories. To help improve the comparability of results, an international scale (IS) for BCR-ABL1 was proposed which is being implemented by testing laboratories worldwide. This is being achieved most commonly by the derivation of laboratory-specific conversion factors… CONTINUE READING
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