Molecular modulation of recombinant rat alpha1beta2gamma2 GABA(A) receptor channels by diazepam.

Abstract

Recombinant gamma-aminobutyric acid (GABA(A)) receptor channels containing alpha1beta2gamma2-subunits were transiently expressed in HEK293 cells. Modulation by diazepam (DZ) was investigated using the patch-clamp technique with a device for ultra-fast solution exchange. GABA activated Cl(-)-currents were potentiated when DZ > 0.1 microM was added to non… (More)

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@article{Krampfl1998MolecularMO, title={Molecular modulation of recombinant rat alpha1beta2gamma2 GABA(A) receptor channels by diazepam.}, author={Klaus Krampfl and Alexandra Lepier and Klaus Jahn and Charles H. Franke and Johannes Bufler}, journal={Neuroscience letters}, year={1998}, volume={256 3}, pages={143-6} }