Molecular modulation of calcium oxalate crystallization by osteopontin and citrate.

  title={Molecular modulation of calcium oxalate crystallization by osteopontin and citrate.},
  author={S. Roger Qiu and Andrzej Wierzbicki and Chris A Orme and Anita M. Cody and John R. Hoyer and George H. Nancollas and Salvador Zepeda and James J De Yoreo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 7},
Calcium oxalate monohydrate (COM), which plays a functional role in plant physiology, is a source of chronic human disease, forming the major inorganic component of kidney stones. Understanding molecular mechanisms of biological control over COM crystallization is central to development of effective stone disease therapies and can help define general strategies for synthesizing biologically inspired materials. To date, research on COM modification by proteins and small molecules has not… CONTINUE READING
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