Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines

@article{Efferth2002MolecularMO,
  title={Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines},
  author={Thomas H Efferth and A. Sauerbrey and M. Halatsch and Douglas D. Ross and Erich Gebhart},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2002},
  volume={367},
  pages={56-67}
}
Homoharringtonine (HHT) is an ester of cephalotaxine (CET), both of which derive from the Chinese coniferous tree Cephalotaxus hainanensis. HHT inhibited tumor cell growth at molar ranges comparable to established cytostatic drugs, whereas CET was 3–4 orders of magnitude less active. Inhibition concentration 50% (IC50) values of CET and HHT were… CONTINUE READING