Molecular modes of action of artesunate in tumor cell lines.

  title={Molecular modes of action of artesunate in tumor cell lines.},
  author={Thomas Efferth and A. Sauerbrey and Armin Olbrich and Erich Gebhart and Pia Rauch and H. Oliver Weber and Jan G. Hengstler and Marc Eric Halatsch and M. Volm and Kenneth D. Tew and Douglas D. Ross and Jens Oliver Funk},
  journal={Molecular pharmacology},
  volume={64 2},
A profound cytotoxic action of the antimalarial, artesunate (ART), was identified against 55 cancer cell lines of the U.S. National Cancer Institute (NCI). The 50% inhibition concentrations (IC50 values) for ART correlated significantly to the cell doubling times (P = 0.00132) and the portion of cells in the G0/G1 (P = 0.02244) or S cell cycle phases (P = 0.03567). We selected mRNA expression data of 465 genes obtained by microarray hybridization from the NCI data base. These genes belong to… 

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