Molecular models of protein kinase 6 from Plasmodium falciparum.

  title={Molecular models of protein kinase 6 from Plasmodium falciparum.},
  author={Karisa Karla Manhani and Helen A. Arcuri and Nelson Jos{\'e} Freitas da Silveira and Hugo Brand{\~a}o Uch{\^o}a and Walter Filgueira de Azevedo and Fernanda Canduri},
  journal={Journal of molecular modeling},
  volume={12 1},
Cyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the… CONTINUE READING