Molecular modelling of miraculin: Structural analyses and functional hypotheses.

@article{Paladino2008MolecularMO,
  title={Molecular modelling of miraculin: Structural analyses and functional hypotheses.},
  author={Antonella Paladino and Susan Costantini and Giovanni Colonna and Angelo M. Facchiano},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={367 1},
  pages={
          26-32
        }
}
Miraculin is a plant protein that displays the peculiar property of modifying taste by swiching sour into a sweet taste. Its monomer is flavourless at all pH as well as at high concentration; the dimer form elicits its taste-modifying activity at acidic pH; a tetrameric form is also reported as active. Two histidine residues, located in exposed regions, are the main responsible of miraculin activity, as demonstrated by mutagenesis studies. Since structural data of miraculin are not available… CONTINUE READING

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