Molecular modeling tools and approaches for CFTR and cystic fibrosis.

Abstract

Cystic fibrosis is a multi-faceted disease resulting from the dysfunction of the CFTR channel. Understanding the structural basis of channel function and the structural origin of the defect is imperative in the development of therapeutic strategies. Here, we describe molecular modeling tools that, in conjunction with complementary experimental tools, lead… (More)
DOI: 10.1007/978-1-61779-117-8_23

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Cite this paper

@article{Serohijos2011MolecularMT, title={Molecular modeling tools and approaches for CFTR and cystic fibrosis.}, author={Adrian W. R. Serohijos and Patrick H. Thibodeau and Nikolay V. Dokholyan}, journal={Methods in molecular biology}, year={2011}, volume={741}, pages={347-63} }