Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors

@article{Morde2009MolecularMS,
  title={Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors},
  author={Varun A. Morde and Mushtaque S. Shaikh and Raghuvir R. S. Pissurlenkar and Evans C. Coutinho},
  journal={Molecular Diversity},
  year={2009},
  volume={13},
  pages={501-517}
}
The search for new antimalarial agents is necessary as current drugs in the market become vulnerable due to the emergence of resistance strains of Plasmodium falciparum (P. falciparum). The biosynthetic pathway for fatty acids has been recognized and validated as an important drug target in P.falciparum. One of the important enzymes in this pathway that has… CONTINUE READING